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首页> 外文OA文献 >Corneal biomechanical properties from two-dimensional corneal flap extensiometry: application to UV-riboflavin cross-linking.
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Corneal biomechanical properties from two-dimensional corneal flap extensiometry: application to UV-riboflavin cross-linking.

机译：二维角膜瓣延伸法测定角膜的生物力学性能：应用于紫外线-核黄素交联。

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摘要

Corneal biomechanical properties are usually measured by strip extensiometry or inflation methods. We developed a two-dimensional (2D) flap extensiometry technique, combining the advantages of both methods, and applied it to measure the effect of UV-Riboflavin cross-linking (CXL). Corneal flaps (13 pig/8 rabbit) from the de-epithelialized anterior stroma (96 μm) were mounted on a custom chamber, consisting of a BK7 lens, a reflective retina, and two reservoirs (filled with Riboflavin and silicone oil). Stretching the corneal flap during five pressure increase/decrease cycles (0-30 mm Hg) changed the refractive power of the system, whose Zernike aberrations were monitored with a ray-tracing aberrometer. Porcine flaps were used to test the system. Rabbits were treated with CXL unilaterally in vivo following standard clinical procedures. Flaps were measured 1 month postoperatively. An analytical model allowed estimating Young's modulus from the change in surface (strain) and pressure (stress). Confocal microscopy examination was performed before, and at different times after CXL. Flap curvature changed with increased function of IOP in pig flaps (23.4 × 10 -3 D/mm Hg). In rabbit flaps curvature changed significantly less in 1 month post CXL (P = 0.026) than in untreated corneas [17.0 vs. 6.36 millidiopter (mD)/mm Hg]. Young's modulus was 2.29 megapascals (MPa) in porcine corneas, 1.98 MPa in untreated rabbit corneas, and 4.83 MPa in 1 month post CXL rabbit corneas. At the same time, highly reflective structures were observed in the rabbit midstroma after treatment. 2D flap extensiometry allows estimating corneal elasticity in vitro. The measurements are spatially resolved in depth, minimize the effects of corneal hydration, and preserve the integrity of the cornea. The method proved the efficacy of CXL in increasing corneal rigidity after 1 month in rabbits. © Association for Research in Vision and Ophthalmology
机译：角膜的生物力学性能通常通过带状拉伸或充气方法进行测量。我们结合了这两种方法的优点，开发了二维（2D）皮瓣引伸技术，并将其应用于测量UV-核黄素交联（CXL）的效果。将来自上皮化的前基质（96μm）的角膜瓣（13头猪/ 8只兔子）安装在定制腔室中，该腔室由BK7晶状体，反射性视网膜和两个储液槽（充满核黄素和硅油）组成。在五个压力增加/减少周期（0-30毫米汞柱）中拉伸角膜瓣，改变了系统的屈光力，该系统的Zernike像差通过光线跟踪像差仪进行监控。猪皮瓣用于测试系统。按照标准临床程序，在体内用CXL单面治疗兔子。术后1个月测量皮瓣。一个分析模型可以根据表面（应变）和压力（应力）的变化估计杨氏模量。共聚焦显微镜检查在CXL之前和之后进行。皮瓣曲率随猪皮瓣IOP功能的增加而变化（23.4×10 -3 D / mm Hg）。在CXL后1个月，兔皮瓣曲率变化明显小于未治疗的角膜[17.0对6.36毫屈光度（mD）/ mm Hg]。猪角膜的杨氏模量为2.29兆帕斯卡（MPa），未经处理的兔角膜的杨氏模量为1.98 MPa，CXL兔角膜术后1个月的杨氏模量为4.83 MPa。同时，在处理后的兔中基质中观察到高反射结构。 2D皮瓣引伸术可估计体外角膜弹性。测量在空间上进行深度解析，最大程度地减少了角膜水化的影响，并保留了角膜的完整性。该方法证明了CXL可以提高兔子1个月后角膜硬度。 ©视觉与眼科研究协会

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